Editor-in-Chief

• Prof. Dr. G. J. Peters
  acting Head for the Laboratory Medical Oncology, VU University Medical Center, Netherlands.
  The major research interests of Prof. Peters include all aspects of pharmacology of anticancer agents, with emphasis on antifolates, other antimetabolites, platinum analogs, taxanes and more recently anti-signalling agents and third generation targeted-agents. The focus is on the improvement of treatment of lung, colon and pancreatic cancer, either by optimizing combinations or by identification of resistance genes. For the latter mutations and genetic polymorphisms in these genes are being studied, particularly in those encoding for transport of folates (influx and efflux pumps), metabolism of (anti)-folates and repair and transport enzymes involved in resistance to platinum drugs.. Another major research line focuses on the role of various multidrug-resistance associated proteins (MRPs) and breast cancer associated resistance protein (BCRP). These transporters also play an important role in the uptake of orally administered drugs from the gut, which is studied in model systems derived from mucosal cells.