Journal of Allergy and Asthma

Journal of Allergy and Asthma

ISSN 2054-9873
Original Research

Relationship between cysteinyl leukotrienes and nitric oxide in the pathogenesis of asthma in obesity

Michael J. Coffey*, Barbara Torretti and Alan Baptist

*Correspondence: Michael J. Coffey coffeym@umich.edu

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Immunology, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA.

Abstract

Background: Obesity has become a lot more prevalent recently, and its involvement with pathogenesis of asthma is frequently investigated.

Aims: We hypothesize that altered plasma adipoikines and exhaled nitric oxide (NO) levels in obese subjects upregulate inflammation in asthmatics. We examined the hypothesis that the inflammatory mediators, cysteinyl leukotrienes (cys-LT) which are regulated by leptin and NO, play a role in the pathogenesis of airway inflammation in obese asthmatics.

Methods: We studied asthmatics (n=59) and non-asthmatics (n=58), both obese and non-obese, and further analyzed by gender. We examined plasma leptin, and fractional exhaled nitric oxide (FeNO), in obese and non-obese asthmatics and non-asthmatics. In addition, we measured urinary cys-LT levels in these subjects.

Results: Plasma leptin was increased in asthmatics compared to non-asthmatics (34.5±31 vs. 27.0±26, p=0.038), specifically in obese female asthmatics compared to obese male asthmatics (65.1±22.5 vs. 26.2±15.9 ng/ml, p=0.01). FeNO were decreased in obese compared to non-obese asthmatics (17.8±9.3 vs. 29.5±22.4, p=0.04), an effect that was most noted in female asthmatics. Urinary cys-LT levels were elevated in female asthmatic (7.2±2.9 vs. 5.0±1.8, p=0.002), especially in older heavier subjects. The ratio of urinary cys-LT to FeNO was elevated in obese female asthmatics.

Conclusions: Pro-inflammatory leptin and anti-inflammatory NO are altered in obese asthmatics. These mediators may regulate cys-LT. The group of subjects with elevated cys-LT/FeNO ratios may be a target for selective therapy.

Keywords: Obesity, leptin, nitric oxide, eicosanoid, airway

ISSN 2054-9873
Volume 4
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