Figure 1 : Schematic diagram showing the biosynthesis of mature hTTR protein and its various structural domains.

The figure also highlights some of the the key natural mutation sites with either pathological or non-pathological consequence as well as the proposed proteolytic cleavage site indicated by a vertical arrow with the amino acid sequence. NT: N-terminal; CT: C-terminal. The mutations are indicated in vertical solid and dotted lines. The dotted line mutation is known to cause rapid aggregation of hTTR and high degree of pathogenic amyloidosis. The solid thick line mutations are known to cause less aggregation.

Basak et al.Biochemical Compounds  2016 4:5DOI : 10.7243/2052-9341-4-5