Monthly Archives: July 2015

Transdermal delivery of xenon from lipophilic solution and water

Xenon has been considered as an ideal anaesthetic agent. Also, scientific literature presents evidence of the neuroprotective effects of xenon in treatment of traumatic and ischemic brain injury. Data suggest that blockade of NMDA receptors in the nervous system by xenon plays a key role in neuroprotective effects of this agent. Recently, NMDA receptors have been found in the axons of human skin and in the keratinocytes of the epidermis. These receptors are involved in skin barrier function, calcium regulation, and dermatitis development. If this gas penetrates into the skin, we can expect a similar blocking effect of xenon onĀ  skin NMDA receptors. Good source of xenon to the skin can be lipophilic liquid products in which xenon dissolves in a large amount. Moreover, xenon well it penetrates through the water. Therefore as a xenon source may be any emulsion comprising a lipophilic component.

Sufficient to take oil (or emulsion) and dissolve the xenon gas, and this oil (or emulsion)with xenon applied to the skin. Within 2 hours of xenon from oil (or emulsion) will diffuse into the skin. At this time xenon can block hyperactive NMDA receptors. Then xenon diffuses into the dermis and may penetrate into the blood capillaries and blood.

These first experiments were done on rat skin preparations. Therefore, for practical use of the results is necessary to continue this work.