• Destructive properties of formalin on human otoconia
    Formalin is not suitable for preservation of the composite structure of human otoconia because of the dissolution of the calcite component by chemical reaction with water (anisotropic dissolution). A suitable medium for long-term preservation of intact and degenerate otoconia is to be found in pure ethanol.
    J Histol Histopathol 2015  2 : 19
  • Expression of glial acidic fibrillary protein delta and E-cadherin in ependymomas
    In this study, we observed that the expression of GFAP-δ could be related with a higher Ki-67 and PCNA Li, high histological grade, presence of neurofilament and loss of E-cadherin and EMA immuno expression.
    J Histol Histopathol 2015  2 : 17
  • Lenalidomide following fludarabine and rituximab in previously untreated CLL
    Fludarabine-based chemoimmunotherapy was the standard of care for previously untreated CLL. While ORRs with these regimens are 90-95%, patients inevitably relapse and further treatment options are necessary. Lenalidomide is a promising agent with activity in CLL.
    Hematol Leuk 2015  3 : 2
  • Anti-Hepatotoxic activity of zingiber officinale against metalaxyl induced hepatotoxicity.
    Metalaxyl causes histological and immunohistochemical changes in liver probably through oxidative stress. Ginger therapy could ameliorate these changes in liver and this may be attributed to its antioxidant and free radicals scavenging properties. This study showed that ginger supplementation may minimize the hazardous effects of metalaxyl.
    J Histol Histopathol 2015  2 : 9
  • Protocols for HIO derived from IPSCs
    Studies confirm that generating HIO is a viable option for producing intestinal epithelial-like cells from human iPSCs. It provides a perspective on key parameters to avoid or look out for, with an advantage of cost-effectiveness of this protocol relative to previously published methods.
    Stem Cell Biol Res 2015  2 : 1
  • Differential systemic MyD88-dependent versus MyD88- independent cytokine ratio
    Statistically higher ratio of MyD88-independent to MyD88-dependent cytokine levels in patients with culture proven gram-negative vs. gram-positive infection supports our original hypothesis. A ratio of cytokines, designed utilizing known pathophysiologic pathways, was a much more robust discriminator of infection type than individual cytokine levels, might have important early clinical decision implications in the care of patients with severe pneumonia.
    Res J Infect Dis 2014  2 : 6
  • DNA-Cytometric Grading of Prostate Cancer Review.
    Review concludes that DNA-ploidy is of either diagnostic or of prognostic value, without considering the methodologic quality of addressed papers.
    Pathol Discov 2014  2 : 7
  • Trends in prenatal diagnosis of congenital anomalies
    Study Conclude that After the change in the prenatal screening programme in Denmark, an increasing number of pregnant women go through the second half of pregnancy knowing that their fetus has a less severe congenital anomaly, which may require treatment postnatally. Knowledge of the psychological impact, both positive and negative, for the parents is very limited.
    J Reprod Biol Health 2014  2 : 1
  • Chronic infections: causes and possible approach to treatment
    At the current state of medicine, with antibiotic resistance being widespread, the search for new approaches to treating infectious diseases is an important task.It is assumed that foci of any persistent microflora are formed because they are necessary for the host, which explains the difficulty of curing chronic infections.
    Res J Infect Dis 2014  2 : 3
  • Use of Negative binomial regression modeling for pediatric peripheral intravenous catheterization
    For pediatric hospital patients in need of fluids quickly, successfully inserting a peripheral intravenous catheter, commonly known as an IV, is often a medical necessity and critical first step in treatment. This procedure is particularly difficult and time consuming.
    J Med Stat Inform 2014  2 : 6