The porcine ROSA26 promoter is ubiquitous and can be utilized in pig transgenesis. Targeting transgenes to ROSA26 locus along with further genetic modification of the pig genome may provide suitable organs for xenotransplantation
Histamine triggers not only direct but also indirect effects in respiratory tract causing both bronchoconstriction and alterations in the eicosanoid synthesis in the lungs. This indirect action of histamine let us to reveal discrepancies in asthmatic inflammation between subjects with hypersensitivity to aspirin and tolerating aspirin well.
Usage of smartphones lead to additional uptake of vaccines, then there is the potential of improving the public health in other areas of vaccine preventable diseases such as MMR, Hepatitis A and B, and influenza vaccines.
Multiple imputation (MI) techniques are approaches to replacing missing values so that complete-data analysis methods may be employed. Our goal was to use multiple imputation techniques to impute missing values for independent variables in a longitudinal study setting
An important step in creating models of mitochondrial disease is to determine specific mechanisms of oxidative damage, or specific triggers for cell death cascades and whether or not these are conserved between distinct causes of pathogenesis.
Joint modeling is the most sophisticated complex approach but enables the repeated biomarker measurements and survival processes to be modelled while accounting for the interrelationship between the two processes. Use of joint modeling in analysis of an HIV data set has been demonstrated.
Use of Enzymes in low water media for large scale organic synthesis is underexploited. There is an understandable diffidence on the part of organic chemists to switch over to these less familiar catalysts. None of the high activity preparations described here involve any skill or technology which is beyond an organic chemist or an organic chemistry laboratory
Curcumin is an exciting potential chemotherapeutic. It is obtained from the roots and rhizomes of the perennial plant Curcuma longa, is cytotoxic towards both ER+ and TNBC cells. Curcumin and its derivatives show future potential as a powerful broad-spectrum treatment for breast cancer.
?-End or acetyl-?-End treatment can suppress the symptoms of Atopic Dermatitis in the mice, and that the effect of the ?-End is induced by the acetylation of the ?-End by Histone acetyltransferase inhibitor