Figure 2 : Regulatory loop among Kaiso, Wnt11/5a and Suz12.

(a). The genes Wnt11 and Wnt5a up-regulate Suz12 expression (supressor of zeste 12) acting in the nucleus as transcriptional factors, as described previously by [15]. (b) Suz12 activates the transcription of Kaiso, as described here in this article and (c) Kaiso and TCF/LEF cooperate to repress the transcription of Wnt11 as described by [14].

Cofre et al.Hematology and Leukemia  2017 5:1DOI : 10.7243/2052-434X-5-1