Figure 2 : Dissolution sequence of human otoconia during treatment with formalin.

(A) Human otoconia specimen before treatment with formalin. (B-F) Human otoconia after 1,3,5,7,11 hours following exposure to formalin. The chemical attack starts in the belly region by surface roughening and proceeds to center of otoconia. When the center of symmetry of otoconia is reached, residues and fragments as parts of the branches are still present. The organic component of toconia keeps the shape of the former composite. ESEM, low vacuum (LV), 15 kV. Scale bar in A (10 μm) corresponds to B-F.

Walther et al.Journal of Histology & Histopathology  2015 2:19DOI : 10.7243/2055-091X-2-19