Table 3 : The different nerve growth factors which secreted by adipose-derived stem cells.


Type of growth factors Related receptor Dependent function References

Nerve growth factor (NGF) TrkA, p75 NTR This factor can promote the biosynthesis of myelin component sheaths in
central and peripheral nerve system and affect on oligodendrocyte differentiation
[44,45]

Brain derived neurotrophic factor (BDNF) TrkB, p75 NTR This factor can prevent neuronal degeneration and improve neurological
functional recovery after transplantation
[46-48]

Glial cell line–derived
neurotrophic factor (GDNF)
GFRα1, RET This factor can prevent motor neuron degeneration and is a highly potent
trophic factor for spinal motor neurons and central noradrenergic neurons
[49-51]

Vascular endothelial growth factor (VEGF) VEGF receptor-2 This factors has angiogenesis activity [52,53]
Basic fibroblast growth factor (bFGF) FGFR1 to FGFR4 This factors has angiogenesis activity
Hepatocyte growth factor (HGF) C-Met receptor This factors has angiogenesis activity
Granulocyte macrophage-colony
stimulating factor (GM-CSF)
GM-CSF-receptor This factors has angiogenesis activity

Transforming growth factor-β (TGF-β) TGFB receptor1 This factor has anti-apoptosis activity

Insulin-like growth factor-1 (IGF-1) IGF1-R This factor has anti-apoptosis and neuroprotection activity [52-56]

Nazem Ghasemi Journal of Histology & Histopathology  2015 2:8DOI : 10.7243/2055-091X-2-8