journal of Histology & Histopathology

Journal of Histology & Histopathology

ISSN 2055-091X
Original Research

Effect of crude latex from Euphorbia tirucalli on DMBA-induced carcinogenesis

Poliana Ribeiro Barroso1*, Flaviana Dornela Verli2, Ricardo Lopes Rocha4, Nadia Lages Lima2, Bethania Alves de Avelar1,3 and Gustavo Eustaquio Brito Alvim de Melo3

*Correspondence: Poliana Ribeiro Barroso poliana.barroso@ict.ufvjm.edu.br

1. Science and Technology Institute (ICT), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil.

Author Affiliations

2. Pathology Laboratory, Department of Basic Sciences, UFVJM, Brazil.

3. Immunology Laboratory, Pharmacy Department, UFVJM, Brazil.

4. Department of Dentistry, UFVJM, Brazil.

Abstract

Background: The aim of the present study was to determine the action of crude latex from Euphorbia tirucalli dissolved in DMSO in animal models of DMBA-induced carcinogenesis.

Methods: Three groups of hamsters received a topical application on edge of the tongue: 1) 0.5% DMBA+crude latex from E. tirucalli in 10% DMSO; 2) 0.5% DMBA+10% DMSO; and 3) 0.5% DMBA+saline solution. Macroscopic and histopathological analyses of the tumors were performed and antibodies were quantified using ELISA after 13 and 20 weeks of treatment.

Results: No statistically significant association was found between the development of cancer of the tongue mucosa and the production of antibodies in the different groups.

Conclusions: Although the data were non-significant, crude latex from E. tirucalli seems to reduce the aggressiveness and size of lesions, but further tests are required.

Keywords: Carcinogenesis, DMBA, tongue, Euphorbia tirucalli

ISSN 2055-091X
Volume 4
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