2. Pathology Laboratory, Department of Basic Sciences, UFVJM, Brazil.
3. Immunology Laboratory, Pharmacy Department, UFVJM, Brazil.
4. Department of Dentistry, UFVJM, Brazil.
Background: The aim of the present study was to determine the action of crude latex from Euphorbia tirucalli dissolved in DMSO in animal models of DMBA-induced carcinogenesis.
Methods: Three groups of hamsters received a topical application on edge of the tongue: 1) 0.5% DMBA+crude latex from E. tirucalli in 10% DMSO; 2) 0.5% DMBA+10% DMSO; and 3) 0.5% DMBA+saline solution. Macroscopic and histopathological analyses of the tumors were performed and antibodies were quantified using ELISA after 13 and 20 weeks of treatment.
Results: No statistically significant association was found between the development of cancer of the tongue mucosa and the production of antibodies in the different groups.
Conclusions: Although the data were non-significant, crude latex from E. tirucalli seems to reduce the aggressiveness and size of lesions, but further tests are required.
Keywords: Carcinogenesis, DMBA, tongue, Euphorbia tirucalli