2. Department of Histopathology, Sheikh Zayed Hospital Lahore, Pakistan.
Background: Oral squamous cell carcinoma (OSCC) is among the frequently reported malignancies in Pakistan having unfavorable prognosis. Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) is a transmembrane glycoprotein that is implicated in tumorigenesis and is recognized as a potential therapeutic target in multiple carcinomas.
Objective: To determine the immuohistochemical expression of EMMPRIN (CD147) in biopsies from OSCC patients in the Pakistani population.
Methods: This descriptive study was conducted in Lahore, Pakistan, comprising 100 OSCC cases presenting, from January 2010 to September 2015. Detailed clinical parameters were recorded. Histological diagnosis & grade was assessed followed by scoring of CD147 immunoexpression into low (score 0-5) and high (score 6-7). The data were analysed using SPSS 21.0. Pearson Chi square and Fisher Exact test were applied. A P value ≤0.05 was considered as statistically significant.
Results: Histologically, conventional OSCC was the most prevalent subtype (92%) followed by oral papillary (6%) and verrucous (2%) carcinomas. Well differentiated carcinomas made most of the tumour burden (64%). 60% carcinomas expressed high score while 40% showed low expression scores. EMMPRIN expression was significantly associated with the degree of differentiation of the tumour (P=0.001).
Conclusions: The findings of the current study highlight the significance of EMMPRIN (CD147) expression in relation to cancer progression thus marking its potential for being an attractive target for immunotherapeutic approaches.
Keywords: EMMPRIN (CD147), oral squamous cell carcinoma (OSCC), immunohistochemistry