Journal of Anesthesiology & Clinical Science

Journal of Anesthesiology & Clinical Science

ISSN 2049-9752
Original Research

Administration of low dose of glucose suppresses catabolism under general anaesthesia maintained with remifentanil

Shinichiro Yoshimura1*, Maiko Tomita1, Nobuyoshi Kusama1, Hiroyuki Hirate1, Takeshi Sugiura1, Takafumi Azami2 and Kazuya Sobue1

*Correspondence: Shinichiro Yoshimura s.yoshimura0829@gmail.com

1. Department of Anesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Author Affiliations

2. Department of Pathophysiology (Anesthesiology), Nagoya City University School of Nursing, Nagoya, Japan.

Abstract

Background: The aim of this prospective randomized controlled study was to examine the optimal rate of glucose administration for preventing catabolism under general anaesthesia maintained with remifentanil.

Methods: Forty-five consecutive patients who were scheduled to undergo elective head and neck surgery were enrolled. The patients were divided into three groups and were treated with a glucose-free solution (Group G0) or a glucose solution at a rate of 0.07 g/kg/h (Group G1) or 0.14 g/kg/h (Group G2). The patients’ plasma glucose, the plasma levels of ketone bodies, free fatty acids (FFA), 3-methylhistidine (3- MH), creatinine (Cr), Branched-Chain Amino Acid (BCAA), and stress hormones were measured every two hours until 6h (T6).

Results: The plasma glucose levels of Group G2 were significantly higher than those of the other groups at T2, T4, and T6 (P<0.01); however, the plasma glucose levels of the three groups did not differ at POD1. Group G0 exhibited significantly higher plasma ketone body and BCAA levels (at T2, T4, and T6) and FFA levels (at T4 and T6). No significant inter-group differences in the plasma levels of 3-MH/Cr or stress hormones were observed.

Conclusions: Intraoperative glucose administration at a rate of 0.07 g/kg/h under general anaesthesia inhibited catabolism without the risk of hyperglycaemia.

Keywords: Intraoperative nutrition, glucose, metabolism, remifentanil

ISSN 2049-9752
Volume 6
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