Figure 1 : UCSC Genome Browser track display of ENCODE and Roadmap data from specific cells and tissues.

A) UCSC Genome Browser image of 3’ region of APAF-1 and gene body of ANKS1B on human assembly hg19 showing chr12q23.1region, NHGRI SNPs, RefSeq Genes, CpG island annotation, Roadmap Chromatin State Segmentation by a Hidden Markov Model (HMM) for Roadmap fetal lung cells, ChIA-PET interactions and enrichment for CTCF in K562 and MCF-7 cells and open chromatin (peaks (Pk) and signals (DS and Sg) for DNaseI-seq and FAIRE data) in A549 lung cancer cells. The HMM utilizes computationally integrated ChIP-seq data for histone marks with associated segment color indicating a weak enhancer annotation for the overlapping SNP region in fetal lung cells/tissue. The overlapping SNP region is also marked by open chromatin in A549 cells and is enriched for CTCF binding and chromatin interactions in MCF-7 cells. Note all MCF-CTCF ChIA-PET interactions are not shown in full for this genomic region or the overlapping SNP region and the data segment has been adapted for the purpose of this illustration to show the relevant interactions only (bars connected by a line; intensity indicative of strength of interaction). The SNP rs1007573 is colored red.

Pathak et al.Journal of Cancer Therapeutics and Research  2014 3:1DOI : 10.7243/2049-7962-3-1