Journal of Cancer Therapeutics & Research

Journal of Cancer Therapeutics & Research

ISSN 2049-7962
Original Research

Procathepsin D in cancer development

Vaclav Vetvicka

Correspondence
Correspondence

Correspondence: Vaclav Vetvicka vaclav.vetvicka@louisville.edu

Author Affiliations :

University of Louisville, Department of Pathology, Louisville, KY 40202 USA.


Abstract

Over thirty years of research showed that procathepsin D is overexpressed and secreted by cells of several tumor types including lung, breast and prostate cancer. After secretion, it exhibits growth factor –like mitogenic activity. Subsequent in vivo and in vitro studies strongly support the hypothesis that the mitogenic effects are mediated via its activation peptide. Another potential cancer-related role of procathepsin D is the effect on resistance of cancer cell to chemotherapeutic drugs. The purpose of this review is to summarize the two major roles of procathepsin D in cancer development.

Keywords: cathepsin D, procathepsin D, activation peptide, cancer, breast, lung, prostate, proliferation, siRNA, growth factro

ISSN 2049-7962
Volume 1
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