2. Department of Biochemistry & Molecular Biology, University of California, Riverside, CA, USA.
3. Department of Pathology, Kaiser Fontana Medical Center, Fontana, CA, USA.
4. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
5. Department of Neurosurgery, Kaiser Fontana Medical Center, Fontana, CA, USA.
Introduction: Collision lesions of the sella involving pituitary adenomas and Rathke's cleft cysts (RCC) are considered a rare entity. Pre-operative diagnosis is challenging due to the variable MRI findings associated with RCC and similar clinical presentations as pituitary adenomas.
Case report: We report two collision lesions involving a non-functional pituitary adenoma with RCC and a plurihormonal adenoma producing prolactin and adrenocorticotrophic hormone with RCC. Both lesions were diagnosed with histopathological analysis and successfully treated with endoscopically-guided transnasaltransphenoidal surgery.
Conclusion: The diagnosis of pituitary ademonas with coexisting RCC should be considered when a cyst is visualized within, or adjacent to, pituitary adenomas detected by MRI, or when cystic contents with varying viscosities and color are discovered intraoperatively.
Keywords: Brain tumor, collision sellar lesions, rathke's cleft cyst, pituitary adenoma, prolactinoma