2. Department of Pathology, National Cancer Institute, Tripoli street, Misurata, Libya.
3. Department of Surgery, National Cancer Institute, Tripoli street, Misurata, Libya.
Background: We tried to evaluate tubular differentiation in the paraffin sections of 130 Libyan breast cancers to distinguish the less aggressive variants of infiltrating breast cancer from other variants and to found the relationship with clinicopathological features. We also compared our results with corresponding results on Finnish, and Nigerian female breast cancer patients.
Methods: Histological samples from 130 patients of Libyan breast cancer were retrospectively studied by estimated the fraction of fields with tubular differentiation (FTD). The samples were screened at x10 magnification and the presence or absence of malignant tubular structures in each microscopic field was registered. They were compared with different clinicopathological features, and patient's survival.
Results: The mean (±SD) value of FTD in Libya 23.4±21.6%, was higher than in Nigeria. but lower than reported in European breast cancer. There was statistically significant correlation between the FTD and some clinicopathological features, with the strongest association observed for large tumor (p < 0.0001). There was also correlation between FTD and histological grade (p = 0.001) and lymph node (LN) status (p = 0.007). The correlation with tumor staging was almost significant (p = 0.07).
Conclusions: The results indicated that FTD are reliable prognostic indicators in Libyan female breast carcinomas, as they were among Finnish and Nigerian females. The FTD is a good parameter for identifying the aggressive tumor phenotype and provide significant prognostic support. The cut-offs (30% and 50%) might be applied as quantitative criterium for Libyan breast cancer to separate the patients into good, moderate and bad prognosis groups. The survival analysis indicated that short survival time was associated with low FTD values.
Keywords: Female breast cancer, fraction of fields with tubular differentiation, survival, prognosis, libya, finland, nigeria