Journal of Diabetes Research & Clinical Metabolism

Journal of Diabetes Research & Clinical
Metabolism

ISSN 2050-0866
Original Research

Effect of dehydroepiandrosterone (DHEA) on vascular function in postmenopausal women with diabetes: a randomized controlled trial

Amal Shibli-Rahhal1*, William Haynes1, Christine Sinkey2 and Joseph S. Dillon1,3

*Corresponding author: Amal Shibli-Rahhal amal-rahhal@uiowa.edu

1.Division of Endocrinology, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, USA.


Author Affiliations

2.Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, USA

3.Research Service, VA Medical Center, Iowa City, Iowa 52242, USA..

Abstract

Background: DHEA stimulates endothelial nitric oxide (NO) production in vitro and its prolonged use in humans improves vascular function. It is believed that this effect is mediated by metabolism of DHEA to androgens and estrogens. We hypothesized that DHEA action is mediated by a rapid, receptor-ependent, endothelial NO production pathway. We tested this hypothesis by studying the acute effect of a single oral dose of DHEA on vascular function in postmenopausal diabetic women.

Design and Methods: This was a double blind, randomized, placebo controlled, cross-over study. Nine postmenopausal women with type 2 diabetes and 5 age- and weight- matched controls received 50 mg of DHEA or placebo in a random order one week apart. We examined forearm resistance vessel responses to intra-arterial nitroprusside, acetylcholine and verapamil.

Results: There was no difference in baseline characteristics and steroid hormone levels between the groups. Following administration of DHEA, steroid hormone concentrations increased in both diabetics and controls indicating adequate absorption and metabolism of DHEA. Prior to administration of arterial vasodilators, there was no difference in baseline forearm blood flow between diabetics and controls and within each group in response to DHEA versus placebo. There was also no difference in the vasodilator-induced increment in blood flow between diabetics and controls and within each group in response to DHEA versus placebo.

Conclusions: In postmenopausal women with diabetes, DHEA did not have any acute effect on basal or vasodilator stimulated forearm blood flow, despite evidence of systemic absorption and adequate vascular responses to endothelium and non-endothelium dependent vasodilators.

Keywords: vasodilator, endothelium, nitric oxide, postmenopausal

ISSN 2050-0866
Volume 1
Abstract Download