Journal of Diabetes Research & Clinical Metabolism

Journal of Diabetes Research & Clinical
Metabolism

ISSN 2050-0866
Short report

Peripartum changes in the orexigenic CNS peptide neuropeptide-Y in gestational diabetics

Raymond M. Anchan1,2,*, Jennifer Lindsey2, Edward Newton1, John Thyfault3,4 and James DeVente1

*Correspondence: Raymond M. Anchan ranchan@partners.org

1. Department of Obstetrics and Gynecology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA.


Author Affiliations

2. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

3. Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA.

4. Department of Nutrition and Exercise Physiology and Internal Medicine, Division of Gastroenterology and Hepatology, University of Missouri School of Medicine, Columbia, MO 65211, USA.

Abstract

Background: Development of relative insulin resistance during pregnancy is a normal physiologic change related to placental lactogen and pregnancy-associated elevated lipid concentrations. Several studies have investigated the role of tissue response, tyrosine kinase insulin receptor phosphorylation, and other cytokines that might contribute to development of such resistance. In this study, we specifically investigate the accompanying changes in concentrations of the orexigenic neurotransmitter neuropeptide Y (NPY) during pregnancy with the development and resolution of insulin resistance in gestational diabetics. Given that increased NPYergic activity is associated with increased eating behavior and body weight, we hypothesize levels of the central nervous system (CNS) peptide NPY will shift, along with other factors such as adiponectin, leptin, and ghrelin, in the development and resolution of gestational diabetes mellitus.

Methods: Antepartum and postpartum plasma concentrations of NPY, leptin, ghrelin, tumor necrosis factor-alpha, glucose, and insulin were measured in gravid patients that were healthy (N=22), class A1 and A2 gestational diabetics (N=8), or type 2 diabetics (N=4). Homeostatic Model Assessment of insulin resistance was also calculated. Data was analyzed using a t-test and considered significant with p<0.05.

Results: We demonstrate that during the third trimester, class A2 gestational diabetics display an elevated NPY concentration. This elevated NPY begins to resolve immediately postpartum, normalizing by the patient's 6 week postpartum visit. The associated Homeostatic Model Assessment of insulin resistance index (HOMA) is consistent with these observations showing a concomitant elevation of HOMA intrapartum with improved insulin resistance within 24 hours postpartum.

Discussion: Collectively, these results suggest a role for central nervous system involvement in the development of insulin resistance during gestational diabetes. Additionally, rising NPY levels during pregnancy may warrant routine patient surveillance for the development of occult insulin resistance and the obstetrical management of the same.

Keywords: Neuropeptide Y, insulin resistance, gestational diabetes, pregnancy

ISSN 2050-0866
Volume 2
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