Table 1 : The effect of changing surfactant percentage and pressure on particle size, zeta potentials and poly dispersibility index (Pd.I) of formulations. In this chart O= oil, W= water and S= surfactant.


Name of formulations O% W% S% Homogenization Pressure (bar) Number of homogenization cycles Z-Average
(nm)
Pd.I Zeta Potential (mv)

SLN1 10 89 1 250 5 227±7.5 0.203 ± 0.016 -50.5± 2.3
SLN2 10 89 1 500 5 204±4.7 0.198 ± 0.014 -49.2± 1.8
SLN3 10 89 1 750 5 181±3.5 0.264 ± 0.023 -52.1± 2.0
SLN4 10 89 1 1000 5 167±8.1 0.248 ± 0.015 -51.9± 1.3
SLN5 10 88 2 250 5 217±7.5 0.136 ± 0.022 -48.5± 2.4
SLN6 10 88 2 500 5 198±3.5 0.256 ± 0.017 -49.8± 1.1
SLN7 10 88 2 750 5 169±2 0.168 ± 0.024 -52.8± 1.7
SLN8 10 88 2 1000 5 147±4.5 0.126 ± 0.015 -52.5± 1.5
SLN9 10 87 3 250 5 223±6 0.181 ± 0.013 -40.1± 1.8
SLN10 10 87 3 500 5 203±4.5 0.261 ± 0.023 -41.2± 1.4
SLN11 10 87 3 750 5 171±4.1 0.246 ± 0.019 -40.8± 2.3
SLN12 10 87 3 1000 5 158±2.08 0.260 ± 0.021 -36.9± 1.6

Farboud et al.Journal of Pharmaceutical Technology and Drug Research  2013 2:13DOI : 10.7243/2050-120X-2-13