Table 3 : Formulation loaded with tretinoin in different cycles and fixed pressure.


Name of formulation   Homogenization Pressure (bar) Number of homogenization
cycles
Z-Average (nm) Pd.I Zeta Potential (mv) EE (%)

Tre-SLN1   1000 3 134±3.05 0.264 ± 0.009 -41.6 ± 2.1 93.77  ± 0.38
Tre-SLN2   1000 5 128±2.6 0.124 ± 0.021 -46.3 ± 1.9 91.62  ± 0.49
Tre-SLN3   1000 7 124±3.6 0.321 ± 0.016 -44.7 ± 2.5 91.59  ± 0.31
Tre-SLN4   1000 9 118±1.5 0.157 ± 0.013 -43.2 ± 2.6 90.32  ± 0.52

Farboud et al.Journal of Pharmaceutical Technology and Drug Research  2013 2:13DOI : 10.7243/2050-120X-2-13