Table 5 : Percent of drug release from different formulations. Mean difference with p<0.05 were considered significant using one-way ANOVA with Tukey post hoc. Asterisk represents the mean difference with p<0.05 in comparison to conventional formulations.


Formulation Tretinoin Cons. Cinitial (µg) Cmax (µg) tmax (hr) Amount of drug released till  tmax  (µg) Percent of drug released till tmax

SLN 0.01 % 35 31.79 6* 31.8 90.82%
Cream- SLN 0.01 % 32 28.80 4* 28.9 90%
Iranian cream (Pars Daru) 0.05 % 240 233.89 3 233.9 97.45%
Retin_A 0.05 % 180 168.50 3 167.7 93.45%
Base cream 0.01 % 45 43.68 3 43.7 97.06%

Farboud et al.Journal of Pharmaceutical Technology and Drug Research  2013 2:13DOI : 10.7243/2050-120X-2-13