Table 2 : Key pharmacokinetic parameters of the formulations. Explanations are given in the text.


Formulation Cmax [pg/ml] Tmax [hours] AUC after 8h [pg*h/ml]

Andriol in Tween 80solution (“fasted”) 2,483 2 8,542
Andriol in castorOil/Lauroglycol (“fed”) 6,408 1 13,105
TU Nanosuspension 3,481 2 6,667
T Nanosuspension 3,682 1 4,312
NLC 30% Dynasan(approx. 600nm) 5,533 1 10,208
NLC 30%  Dynasan (approx. 200nm) 6,036 1 13,950
NLC 15%  Dynasan (approx. 200nm) 8,589 1 12,933
NLC 15%  stearic acid (approx. 200nm) 6,675 2 11,976

M Keck et al.Journal of Pharmaceutical Technology and Drug Research  2013 2:4DOI : 10.7243/2050-120X-2-4