Journal of Pharmaceutical Technology & Drug Research

Journal of Pharmaceutical Technology &
Drug Research

ISSN 2050-120X
Original Research

Pharmacokinetics and tissue distribution of SU2162, a novel anticancer drug, after intravenous administration in rats

Zaiyou Tan*, Hui Yang, Ruisi Yan, Ruiling Liu, Xue Li, Qing Ye, Wanshen Guan, Xiaolu Zhang, Yuqing Huang, Chunmei Tong and Wenfei Chen

*Correspondence: Zaiyou Tan tanzaiyou@medmail.com.cn

Author Affiliations

School of Pharmacy, Guangdong Pharmaceutical University, Guangdong, 510006 People's Republic of China.

Abstract

Background: SU2162, a novel anticancer agent, was investigated in the rat, and pharmacokinetics and tissue distribution were observed. These data will be used to design a SU2162 dosage form for clinical use.

Methods: After IV administration of SU2162, HPLC with UV detection was used to analyze rat samples. A two compartment model was used to evaluate the pharmacokinetics of SU2162.

Results: SU2162 pharmacokinetics in the rat depicts a two-compartment model, and the weighting coefficient was 1/c2. The distribution half life (T1/2α) was 0.1066 h; the elimination half life (T1/2kel) was 0.3910 h. SU2162 was distributed widely in tissues studied. The AUC in the spleen was the highest of all the tissues assayed (6.7685 mg/l*h). The LZ in the liver was the greatest (1.5729 1/h) but liver MRT was the smallest (0.6760 h).

Conclusion: SU2162 is eliminated quickly in the rat and distributes to tissues extensively, and warrants further development as anticancer candidate.

Keywords: SU2162, pharmacokinetics, tissue distribution, compartment model, HPLC

ISSN 2050-120X
Volume 3
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