Table 2 : Plasma and blood pharmacokinetics of AS after the
intravenous administration of AS, 10 mg/kg, to control and DM rats.


  Control DM P value

Plasma pharmacokinetics

V1 (mL) 634±153 916±142 0.004
V2 (mL) 164±52 290±64 0.247
k12 (1/min) 0.0121±0.0042 0.0083±0.0016 0.329
k21 (1/min) 0.0461±0.0110 0.0302±0.0068 0.931
kel (1/min) 0.248±0.022 0.207±0.021 0.429
t1/2α(min) 2.76±0.32 3.33±0.34 0.247
t1/2β (min) 19.3±3.9 40.4±17.7 0.177
AUC (µg/mL•min) 19.0±3.1 12.5±1.7 0.329

Blood pharmacokinetics

V1 (mL) 1315±309 1295±264 0.715
V2 (mL) 1411±564 2201±722 0.662
k12 (1/min) 0.0297±0.0027 0.0553±0.0085 0.052
k21 (1/min) 0.0367±0.0068 0.0405±0.0069 0.931
kel (1/min) 0.246±0.032 0.223±0.019 0.537
t1/2α (min) 2.63±0.35 2.47±0.18 0.931
t1/2β (min) 26.8±7.4 25.3±3.8 0.584
AUC (µg/mL•min) 9.08±0.93 8.61±1.57 0.715

V1, V2: distribution volume of the central or peripheral compartment.
k12, k21: transfer rate constant from the central to peripheral or peripheral
to central compartment. kel: elimination rate constant from the central
compartment. t1/2α, t1/2β: half-life of the distribution or elimination phase.
AUC: area under the plasma or blood concentration vs. time curve from
0 to infinity. Each value represents the mean ± S.E. of control (n=5) and
DM (n=6) rats. Differences in the means were tested using the
Mann-Whitney U test.

Sugioka et al.Interactive Medicinal Chemistry  2014 2:1DOI : 10.7243/2053-7107-2-1