Table 3 : Plasma and blood pharmacokinetics of DHA after the
intravenous administration of AS, 10 mg/kg, to control and DM rats.


  Control DM P value

Plasma pharmacokinetics

V1/Fm (mL) 663±144 580±53 0.931
V2/ Fm (mL) 352±110 243±21 0.931
k12 (1/min) 0.0420±0.0288 0.0058±0.0008 0.792
k21 (1/min) 0.0299±0.0111 0.0133±0.0009 0.429
kel (1/min) 0.0659±0.0162 0.0454±0.0025 0.537
t1/2α (min) 10.9±3.3 13.1±0.6 0.931
t1/2β (min) 56.8±19.4 62.5±3.9 0.247
AUC (µg/mL•min) 52.5±1.8 59.6±5.4 0.537

Blood pharmacokinetics

V1/ Fm (mL) 736±104 447±35 0.052
V2/ Fm (mL) 382±129 305±36 0.931
k12 (1/min) 0.0064±0.0016 0.0170±0.0027 0.009
k21 (1/min) 0.0154±0.0039 0.0259±0.0052 0.082
kel (1/min) 0.0419±0.0016 0.0398±0.0023 0.429
t1/2α (min) 13.8±1.1 10.5±0.8 0.052
t1/2β (min) 76.4±25.7 50.3±4.1 0.662
AUC (µg/mL•min) 65.1±9.5 88.2±8.4 0.052

V1, V2: distribution volume of the central or peripheral compartment.
Fm: metabolized fraction into DHA. k12, k21: transfer rate constant from the
central to peripheral or peripheral to central compartment. kel: elimination
rate constant from the central compartment. t1/2α, t1/2β: half-life of the
distribution or elimination phase. AUC: area under the plasma or blood
concentration vs. time curve from 0 to infinity. Each value represents the
mean±S.E. of control (n=5) and DM (n=6) rats. Differences in the means
were tested using the Mann-Whitney U test.

Sugioka et al.Interactive Medicinal Chemistry  2014 2:1DOI : 10.7243/2053-7107-2-1