Figure 1 : Covariate (treatment) effect on longitudinal biomarker measurements and survival outcome.

α is the covariate effect on survival time; γ is the covariate effect on the longitudinal biomarker; β is the effect of the
longitudinal biomarker on survival time.

Lim et al.Journal of Medical Statistics and Informatics  2013 1:1DOI : 10.7243/2053-7662-1-1