Table 3 : IPA outputs of top canonical pathways and top associated network functions for different stagesa.


Top Canonical Pathway -log(B-H p-value)

  DCIS-T1   DNA Double-Strand Break Repair by Homologous Recombination 0.481
    B Cell Development 0.405
    PPARα/RXRα Activation 0.405
    Autoimmune Thyroid Disease Signaling 0.405
    Allograft Rejection Signaling 0.405

  T1-T2   Glutathione Metabolism 1.200
    VEGF Signaling 0.330
    mTOR Signaling 0.330
    Hypoxia Signaling in the Cardiovascular System 0.330
    Small Cell Lung Cancer Signaling 1.320

  T2-T3   Ovarian Cancer Signaling 1.270
    Factors Promoting Cardiogenesis in Vertebrates 1.010
    Glioblastoma Multiforme Signaling 0.708
    Cell Cycle: G1/S Checkpoint Regulation 0.708
    Wnt/β-catenin Signaling 0.0179

  Top Associated Network Function Score

  -T1DCIS   Hematological System development and Function, Tissue Morphology, Cellular 35
    Growth and Proliferation 33
    Genetic Disorder, Reproductive System Disease, Developmental Disorder 33
    Cancer, Dematological Diseases and Conditions, Neurological Disease 28
    Gene Expression, Lipid Metabolism, Small Molecule Biochemistry 21
    Carbohydrate Metabolism, Cardiovascular System Development and Function,
Organismal Development
19

  T1-T2   Hematological  Disease,  Organismal  Injury  and  Abnormalities,  Respiratory Disease 44
    Endocrine  System  Development  and  Function,  Lipid  Metabolism,  Small Molecule Biochemistry 42
    RNA Post-Transcriptional   Modification,   Dermatological Diseases and Conditions,
Infectious Disease
40
    Cell Morphology, Cellular Assembly and Organization, Cellular Function and Maintenance 33
    Embryonic Development, Nervous System Development and Function, Organ Development 33

  T2-T3   Cell Cycle, Cellular Growth and Proliferation, Cellular Development 32
    Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry 27
    CellCycle,  Cellular  Development,  Connective  Tissue  Development and Function 22
    Molecular Transport, Nucleic Acid Metabolism, Small Molecule Biochemistry 20
    Cancer, Carbohydrate Metabolism, Endocrine System Disorders 2

Solvang et al.Journal of Medical Statistics and Informatics  2014 2:10DOI : 10.7243/2053-7662-2-10