2. Tbilisi Medical State University, Tbilisi, Georgia.
3. Javakhishvili Tbilisi State University, Tbilisi, Georgia.
Background: Imaging plays a crucial role in the identification, localization and grading of prostate carcinoma. However current imaging methods for the prostate cancer diagnosis are complicated and partially invasive. The drawback of existent imaging method is that they cannot detect prostate carcinoma at early stage of development. Therefore, a key challenge for prostate cancer detection is to use a simple and noninvasive method which will able to detect the cancer with very small dimensions. Correspondingly, the aim of present work was to demonstrate the possibility of using a near infrared light for the prostate cancer detection in vitro.
Methods: Experiments were carried out on prostates obtained after radical prostatectomy. Infrared light emitted diodes were used as illumination sources. Infrared light passing through the prostate was caught by charge-coupled device connected to computer and prostate infrared transillumination images were obtained.
Results: Intensity of near infrared light passing through the noncancerous prostate tissue is nearly homogeneous. Intensity of near infrared light passing through the cancerous outgrowth is lower than the intensity passing through the non-cancerous tissue of the same prostate, thereby cancerous formations are differentiated as the dark areas on the relatively white background. Specially developed software analyzes and processes distribution of intensities of the grayscale images, measures the ratio of their strength, and determines the rate of prostate malignancy.
Conclusions: Obtained results may hold some promise to make an important contribution to the diagnosis of prostate cancer in early stage of its development.
Keywords: Prostate cancer, near infra-red radiation, early diagnosis, transillumination imaging