1. Department of Histology and Embryology, Faculty of Medicine, Charles University, Czech Republic, Europe.
2. Department of Obstetrics and Gynecology, University Hospital, Faculty of Medicine, Charles University, Czech Republic, Europe.
3. Biomedical Centre, Faculty of Medicine in Plzen, Charles University, Czech Republic, Europe.
Endometriosis is serious gynecological disease affecting millions of women world- wide. Despite long periods of intensive studies, the exact mechanisms are still unclear and no cure is in sight. Recently, the theory of angiogenesis being essential for the development and establishment of endometriosis is gaining more and more traction. This article covers not only angiogenesis in general, but also all major parts of angiogenesis found in endometriosis, including miRNA, VEGF, macrophages, inhibitors, and other approaches. This review is focused on present knowledge of the possible involvement of angiogenesis in development and possible treatment of endometriosis.
Keywords: Angiogenesis, endometriosis, microRNA, treatment