Transplantation Technology

Transplantation Technology

ISSN 2053-6623
Review

Potential applications of lipid peroxidation products in renal transplantation

Omotayo O. Erejuwa*, Siti A. Sulaiman and Mohd S. Ab Wahab

*Correspondence: Omotayo O. Erejuwa erejuwa@gmail.com

Author Affiliations

Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia,16150 Kubang Kerian, Kelantan, Malaysia.

Abstract

There has been an increased prevalence of end-stage renal disease (ESRD) in the last decades. This can be attributed to high incidence of chronic diseases such as metabolic disorders, diabetes and hypertension. These diseases are often associated with ESRD, which requires regular dialysis and may later necessitate renal transplantation. The increased demand for renal transplantation has resulted in scarcity of donor kidneys leading to receipt of kidneys from extended criteria donors (ECDs) whose kidneys are susceptible to ischemic-injury. The levels of lipid peroxidation products, which are biomarkers of oxidative stress and damage, have been reported to be elevated in ischemic-injury. Therefore, transplantation of kidneys prone to ischemic-injury poses a great danger or high rate of failure in the recipients. The aim of this mini review is to highlight the potential usefulness or application of lipid peroxidation products in screening donor kidneys for renal transplantation. As a result of machine perfusion (MP), it is now possible to determine certain biomarkers such as lipid peroxidation products in the perfusate which reveal kidneys that have undergone severe ischemic and/or oxidative damage. This will help in screening or identification of kidneys that are unfit for transplantation. Besides, lipid peroxidation products can also be used to monitor or evaluate patient's post-transplant recovery. Thus, measurement of lipid peroxidation products may help to reduce post-transplant failure and improve the quality of life of recipients.

Keywords: Lipid peroxidation products, kidney, extended criteria donors, machine perfusion, renal transplantation

ISSN 2053-6623
Volume 1
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