Table 2 : Cumulative proteoglycan(PG), nitric oxide (NO), prostaglandin E2 (PGE2),
and interleukin-6 (IL-6) release from cartilage into media for experiment 1 when
explants were treated with 0 to 25 μg/mL of eicosapentaenoic acid (EPA)
(Table 1).


  100 LA 6.25 EPA 12.5 EPA 18.75 EPA 25 EPA SEM P-value

PG              

Pre IL-1 101.9 101.0 122.8 96.8 103.9 18.4 0.872
Post IL-1 540.1a 423.2b 452.8ab 526.2a 478.7ab 32.8 0.087
               

NO              

Pre IL-1 15.7 15.2 14.9 15.5 14.8 0.58 0.795
Post IL-1 86.7 77.6 74.7 80.9 76.1 3.9 0.228
               

PGE2              

Pre IL-1 84.0 92.4 71.06 103.7 112.8 19.7 0.584
Post IL-1 917.5 903.3 486.3 865.1 640.4 177 0.346
               

IL-6              

Pre Il-1 63.2 55.9 34.39 36.0 44.8 11.5 0.323
Post IL-1 6390.3 6059.0 6475.7 6194.7 6419.5 724 0.993

Proteoglycan release exhibited trend for a treatment effect (P=0.087). Means with different
letters differ (P<0.05) for a given analyte.

Orth et al.Veterinary Medicine and Animal Sciences  2015 3:4DOI : 10.7243/2054-3425-3-4