Table 3 : Cumulative proteoglycan (PG), nitric oxide (NO), prostaglandin E2 (PGE2), and
interleukin-6 (IL-6) release from cartilage into media for experiment 2 when explants
were treated with 0 to 25 μg/mL of docosahexaenoic acid (DHA)
(Table 1).


  100 LA 6.25 DHA 12.5 DHA 18.75 DHA 25 DHA SEM P-value

PG              

Pre IL-1 70.2 71.1 66.6 72.2 75.8 5.3 0.81
Post IL-1 380.7 347.9 282.8 298.0 312.3 34.7 0.285

NO              

Pre IL-1 14.3 14.5 13.9 13.0 12.3 0.8 0.270
Post IL-1 74.7a 66.12a 52.05b 52.75b 46.58b 4.8 0.001
               

PGE2              

Pre IL-1 22.3a 39.3ab 153.0c 56.3a 104.7bc 24.3 0.008
Post IL-1 1060.1a 431.2b 523.2b 382.3b 474.9b 102 <0.001

IL-6              

Pre IL-1 42.7 43.3 19.0 13.4 7.1 21.6 0.66
Post IL-1 3923.3 4380.1 3446.5 3844.1 3642.7 938 0.967

NO and PGE2 release exhibited a treatment effect (P<0.01). Means with different letters differ
(P<0.05) for a given analyte.

Orth et al.Veterinary Medicine and Animal Sciences  2015 3:4DOI : 10.7243/2054-3425-3-4