2. Professor of Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
3. Lecturer of Oral Medicine, Oral Diagnosis and Periodontology Department, Faculty of Oral and Dental Medicine, SVU, Qena, Egypt.
Microbiota variety is site specific depending on its location in the body and this diversity can get together with human health. At the last decades, inflammation is a primary protective response that sometimes goes away and becomes a main cofactor in the pathogenesis of numerous chronic human diseases, including malignant tumor. As well, microbes have the potency power to influence tumor growth and progression through a wide forms of routes; including alteration of tumor microenvironment, prolonged activation of inflammation, induction of genotoxic restraints and metabolism. In this review, we will set a general overview of inflammation has suspected to provide a major role in the pathogenesis and development of cancer as an important object for advanced cancer biology.
Keywords: Inflammation, Cancer,Cytokine, Tumorigenesis