Figure 2 : (Modified from Grieg et al. [3]) The 6 layered pattern of neocortical neurons.

In humans, this pattern forms during in-utero fetal development during weeks 12 to 20. In the uppermost layer, the CajalRetzius cells (shown in orange) produce reelin, a protein which assists in properly arranging the migrating neurons. Definitions: VZ: Ventricular zone; SVZ: Subventricular zone; SP: Subplate.

Seneff et al.Journal of Autism  2016 3:1DOI : 10.7243/2054-992X-3-1