Biochemical Compounds

Biochemical Compounds

ISSN 2052-9341

Platinum-based anticancer drugs encapsulated liposome and polymeric micelle formulation in clinical trials

Zhou Hang1, Matthew A. Cooper2 and Zyta M. Ziora2*

*Correspondence: Zyta M. Ziora

2. The University of Queensland, Institute for Molecular Bioscience, St Lucia, QLD 4072, Australia.

Author Affiliations

1. The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia QLD 4067, Australia.


Platinum-based anticancer drugs are one of the most widely used drug classes in cancer therapy. Almost half of the chemotherapy regimens used today contains a platinum drug, such as cisplatin or carboplatin. However, the drug resistance and non-specific cytotoxicity ultimately limits broader application of these drugs. Improvement of drug targeting and delivery systems are effective approaches to mitigate these disadvantages. This review focuses on liposome and micelle-based formulations using in the delivery of platinum-based anticancer drugs in clinical trials.

Keywords: Anticancer agents, cisplatin, liposome-based formulations, micelle-based formulations

ISSN 2052-9341
Volume 4
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