Role of regeneration in tissue repairing and therapies

By | August 17, 2015

Present review article emphasizes role of regeneration mechanism in various tissues and its use in organ transplantation for wound healing and repairing. This review also addresses tissue engineering methods and use of new biological scaffold materials and promising candidates such as immunomodulators, adhesions, integrins in tissue repairing and induction of regeneration in injured tissues. This article also explains uses of various stem cell types in transplantation technologies and its applications in regenerative medicine and therapeutics. In addition, role of various molecules of immune cell system, gene cascades and transcription specific proteins (TSPs) and growth factors in formation of microenvironment for differentiation are also explained. Mechanisms of regeneration in various animal tissues such as tendon and ligament, cartilage need progenitor cells show chondrogenic and proliferative potential and form elastic cartilage that needs long-term tissue maintenance. Similarly, regeneration of bone, limbs and local tissues, skeletal myoblasts, cardiac and smooth muscle cells is explained in detail. It makes clear that combined transplantation of specifically-processed human secondary CSs enhance infarct repair through the complementary enhancement of cardiopoietic regenerative and paracrine protective effect that can be maximize for achieving higher therapeutic benefits. Regenerative medicine has wider application in the field of tissue repairing, wound healing and transplantation therapeutics. Mechanism of regeneration in various tissues such neural, skeletal, cardiac, muscular, adipose and gonadial tissues, and bone marrow is described in detail. In addition repairing of adipose tissue damage, regenerative gonadial tissue damage repairing, and restoration of immune power,

Regenerative medicines belong to processes of creating living cells, replacing or regenerating human cells, tissues or organs. However, for repairing of age related effects, physical or biological injuries various biological and tissue engineering methods and stem cell therapies are used to restore the normal function. This article also suggest an urgent need for development of new advanced methods, technologies, bio-matrices, polymers and scaffold materials, and cell based therapies to overcome the problem of disable and injured patients. Regenerative medicine is an inter-disciplinarily innovative research area which has wider applications in the field of oncology, embryology, immunology, physiology, cardiovascular, nephrology, anatomy and clinical biology mainly in organ and tissue transplantation. However, by applying biological and tissue engineering methods self-sustained growth of degenerated or injured organ tissues could be achieved. Truly regenerative tissue re-juvenation has provided life to millions of accidental disabled peoples. No doubt, limb regeneration and its replacement assisted millions of disables to walk or those who have faced accidents and bear brutal multiple injuries in limbs. Moreover, limb regeneration by somatic cell induction and tissue replacement therapies are proved boon for millions. Similarly, repairing of chronically ischemic muscles has provided a grand success in management of CLI (critical limb ischemia) patients. In addition, cases of acute sciatic traction injury could be solved by axial regeneration of nerve cell. It would be possible by unifying growth factors and gene activities more interactive in vivo. Further, cell programming and regenerative factors found in few animals like newts, axolotls and frogs can be used for clinical trials. Thus by studying the regenerative abilities of planarians and its molecular basis tissue injury restoration and healing of wounds in vertebrates are much possible. Hence, landmark innovations are required in the field of regenerative medicine, tissue engineering, and developmental biology for successful tissue repairing and organ transplants to serve the human society.









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