Cardiovascular System

Cardiovascular System

ISSN 2052-4358

Renin Angiotensin System and Coronavirus Disease 2019 (COVID-19): An updated review

Rolando S. Vela Vásquez

Correspondence: Rolando S. Vela Vásquez

Department of Cardiology, Cajamarca Essalud Hospital, 939 Mario Urteaga Avenue, Cajamarca, Perú.


Abnormal Renin-Angiotensin System (RAS) activation has a pivotal role in pathogenesis of cardiovascular or metabolic diseases, known risk factors for poor outcomes in COVID-19. An additional tissue RAS imbalance trough interaction of ‘severe acute respiratory syndrome coronavirus 2’ (SARS-CoV-2) with angiotensin-converting enzyme 2 (ACE-2) seems to play a role in pathogenesis of COVID-19. This interaction has raised some questions about safety of RAS-inhibitors use in COVID-19 patients. On the other hand, potential benefits of RAS-inhibitors use have been suggested. This article presents a brief updated review of renin-angiotensin system (RAS) focusing on interaction with SARS-CoV-2 infection, potential risks or benefits of RAS-inhibitors use, and RAS-related therapeutic targets in COVID-19.

Keywords: Coronavirus disease 2019, COVID-19, angiotensin-converting enzyme 2, renin-angiotensin system, renin-angiotensin system blockers

ISSN 2052-4358
Volume 8
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