Figure 5 : Variability of gene expression among purported generic glatiramer acetate products worldwide.

Significantly different expression of progesterone receptor membrane component 1 (PGRMC1) and interleukin 1-beta (IL-1β) from mouse splenocytes following stimulation
with purported generic GA products prepared by different manufacturers. (Medium: non-reactivated splenocytes; Probioglat® [Mexico]; Escadra® [Argentina];
Hangzhou [China]) [96]. Progesterone receptor membrane component 1 (PGRMC1) is significantly down-regulated by Probioglat® relative to mediumbut not by Escadra®
or Hangzhou. Progesterone is thought to be neuroprotective and play a role in myelin repair [103,104] and to affect the balance between Tregs and Th cells [105]. IL-1β
was significantly downregulated by Probioglat® and Escadra®, but not by Hangzhou. IL-1β is a cytokine associated with Th17 cell development [106].

Jill Conner Journal of Autoimmunity and Cell Responses  2014 1:3DOI : 10.7243/2054-989X-1-3