Figure 5 : The effects of COEE on the plasma histamine concentrations in
NC/Nga mice housed under conventional condition.

The topical application with COEE significantly reduced the histamine concentration
under conventional conditions. The data are presented as the means±S.D.
(n=3 in each SPF group, n=5 in each conventional group).
**: p<0.01 (one-way ANOVA followed by Tukey’s test).
Control: not exposed to any topical preparation.
COEE: treated with a cream containing Corchorus olitorius leaf extract excluding high
molecular weight compounds.
BC: treated with the base cream.

Yokoyama et al.Dermatology Aspects  2014 2:3DOI : 10.7243/2053-5309-2-3