Table 2 : Effect of MAOA SNPs on blood pressure and anxious/depressed mood for girls in the Western Australian Pregnancy Cohort (Raine)
Study at 14 years.


SNP Allele N DBP effect size
in mm/Hg§
(95% CI)
p N SBP effect size
in mm/Hg§
(95% CI)
p N BDI-Y score
effect size§
(95% CI)
p N CBCL/4-18 (SADRS) effect size§ (95% CI) p

rs1181275 AG 477 0.698 0.28 477 1.000 0.30 475 0.100 0.060 469 0.029 0.63
      (-0.566, 1.962)     (-0.736, 2.822)     (-0.002, 0.128)     (-0.090, 0.148)  
rs12843533 AG 475 0.880 0.19 475 -0.102 0.87 473 0.4 <0.001   467 0.126 0.020
      (-0.437, 2.196)     (-1.920, 1.747)     (0.236, 0.603)     (0.019, 0.234)  
rs3027396 AG 476 0.066 0.88 476 -0.406 0.47 474 0.000 0.84 468 -0.142 0.001
      (-0.820, 0.953)     (-1.658, 0.861)     (-0.042, 0.052)     (-0.227, -0.058)  
rs3027399 CG 471 0.042 0.96 471 -0.062 0.90 469 0.200 <0.001   464 0.030 0.68
      (-1.475, 1.560)     (-2.151, 2.067)     (0.109, 0.283)     (-0.113, 0.174)  
rs3027415 AG 474 0.167 0.74 474 0.128 0.68 472 -0.2 <0.001 466 0.059 0.18
      (-0.816, 1.151)     (-1.249, 1.524)     (-0.165, -0.055)     (-0.027, 0.144)  
rs5905859 AC 476 0.496 0.27 476 -0.231 0.66 474 -0.1 0.28 468 -0.204 <0.0001
      (-0.386, 1.378)     (-1.491, 1.044)     (-0.074, 0.022)     (-0.292, -0.116)  
rs5906883 AC 477 -0.034 0.94 477 -0.256 0.63 475 0.000 0.75 469 -0.138 0.002
      (-0.939, 0.871)     (-1.536, 1.038)     (-0.041, 0.057)     (-0.226, -0.050)  
rs5906957 AG 476 -0.082 0.87 476 -0.685 0.31 474 0.000 0.54 468 -0.113 0.020
      (-1.038, 0.874)     (-2.050, 0.697)     (-0.036, 0.069)     (-0.207, -0.018)  
rs6609257 AG 476 0.609 0.15 476 -0.235 0.68 474 0.000 0.87 468 -0.097 0.010
      (-0.217, 1.434)     (-1.394, 0.937)     (-0.048, 0.041)     (-0.174, -0.020)  
rs7052785 AG 477 0.819 0.52 477 -1.784 0.29 475 0.000 0.65 469 -0.355 0.010
      (-1.688, 3.326)     (-5.143, 1.684)     (-0.104, 0.167)     (-0.621, -0.089)  

Girls SBP model adjusted for age, puberty and BMI; Beck’s Depression Inventory for Youth (BDI-Y) model adjusted for Puberty and ever smoked; CBL-SADRS model
adjusted for age and puberty Underlined allele represents risk allele. Bold font represents associations that remained significant after correcting for multiple testing
(i.e. q value corresponding to a p value of ≤0.01). Additive mode of inheritance assumed unless indicated by (representing dominant mode of inheritance) or
(representing recessive mode of inheritance. N represents sample size; p represents p value. Analyses used: §Linear Regression; §Mixed distribution Linear Regression.

Louise et al.Journal of Genetics Study  2014 2:2DOI : 10.7243/2054-1112-2-2