Table 3 : Effect of MAOA SNPs on blood pressure and anxious/depressed mood for boys in the Western Australian Pregnancy Cohort (Raine)
Study at 14 years.


SNP Allele N DBP effect size
in mm/Hg
(95% CI)
p N SBP effect size
in mm/Hg
(95% CI)
p N BDI-Y score
effect size§
(95% CI)
p N CBCL/4-18 (SADRS) effect size§ (95% CI) p

rs1181275 AG 568 1.534 0.10 568 3.000 0.04 562 -0.215 <0.001   560 -0.134 0.03
      (-0.146, 1.680)     (0.152, 5.872)     (-0.289, -0.141)     (-0.256, -0.013)  
rs12843533 AG 567 0.315 0.46 567 0.1 0.91 561 -0.106 0.001 560 -0.020 0.66
      (-0.520, 1.150)     (-1.192, 1.368)     (-0.167, -0.045)     (-0.111, 0.070)  
rs3027396 AG 565 0.275 0.36 565 2.300 0.01 559 -0.039 0.050 559 -0.087 0.01
      (-0.311, 0.861)     (0.465, 4.086)     (-0.078, 0.000)     (-0.153, -0.021)  
rs3027399 CG 541 -0.644 0.23 541 -1.300 0.15 535 0.056 0.12 555 -0.047 0.42
      (-1.693, 0.405)     (-2.880, 0.292)     (-0.015, 0.126)     (-0.160, 0.066)  
rs3027415 AG 566 -0.015 0.96 566 -0.020 0.96 560 -0.041 0.070 559 0.107 0.001
      (-0.666, 0.637)     (-1.015, 0.978)     (-0.086, 0.003)     (0.044, 0.170)  
rs5905859 AC 562 0.410 0.16 562 2.500 0.003 556 -0.070 <0.001 557 -0.034 0.28
      (-0.165, 0.984)     (0.766, 4.333)     (-0.110, -0.032)     (-0.097, 0.028)  
rs5906883 AC 567 0.302 0.32 567 0.900 0.050 561 -0.044 0.030 560 -0.099 0.005
      (-0.298, 0.902)     (-0.032, 1.808)     (-0.084, -0.004)     (-0.167, -0.030)  
rs5906957 AG 567 0.314 0.33 567 2.000 0.030 561 -0.001 0.64 560 -0.077 0.030
      (-0.312, 0.940)     (0.120, 3.994)     (-0.051, 0.031)     (-0.148, -0.007)  
rs6609257 AG 567 0.506 0.08 567 3.000 <0.001 561 -0.038 0.050 560 -0.070 0.020
       (-0.052, 1.065)      (1.282, 4.730)     (-0.075, -0.001)     (-0.130, -0.009)  
rs7052785* AG 567 0.954 0.20 567 6.400 0.005 562 0.072 0.10 560 0.053 0.47
       (-0.494, 2.401)     (1.836, 11.180)     (-0.014, 0.157)     (-0.090, 0.196)  

Boys SBP model adjusted for BMI Systolic blood pressure (SBP): effect size and 95% confidence intervals (95% CI) back transformed; Underlined allele represents
risk allele. Bold font represents associations that remained significant after correcting for multiple testing (i.e. q value corresponding to a p value of ≤0.01). Additive
mode of inheritance assumed unless indicated by *(representing dominant mode of inheritance) or (representing recessive mode of inheritance. N represents
sample size; p represents p value. Analyses used: Linear regression; §Mixed distribution linear regression.

Louise et al.Journal of Genetics Study  2014 2:2DOI : 10.7243/2054-1112-2-2