Figure 1 : Map of probes.

Probes for the dual colour break-apart FISH assay were designed to flank the HLXB9 gene (in red) on chromosome 7 and the ETV6 gene (in green) on chromosome 12. Due to the probes design, a gap is left in the genomic region that includes HLXB9 on 7q36 and ETV6 on 12p13. This may result in the visualisation of double signals (doublets) on the nontranslocated chromosomes in the interphase nuclei (see FISH images in Figure 2).

Tosi et al.Hematology and Leukemia  2015 3:4DOI : 10.7243/2052-434X-3-4