Table 1 : Clinical features, cytogenetic data and FISH findings relative to the patients analysed in this study.


pt Diagnosis   Previous FISH probes Reference Comparison with previous
FISH studies

1 T-ALL
later revised as AML
49,XX,+6,t(7;12)(q36;p13),+8,+19[3]/50,idem,+18 [7] YAC 964c10 (12p13)
Vysis TEL/AML1
ETV6 exon
specific cosmids
YAC HSC7E551
(7q35)
YAC HSC7E526
(7q36)
pt. 4 in [2] Refined chromosome 7
breakpoint

2 AML-M4 48,XY, t(7;12)(q36;p13),+8,+19 YAC 964c10 (12p13)
ETV6 exon
specific cosmids
PAC H_DJ1121A15
(7q36)
Cos 121b1 (7q36)
Cos 227e6 (7q36)
Cos 85c10 (7q36)
Cos 133f02 (7q36)
pt 6 in [2]    





pt 4 in [12]
Confirmed previous findings

3 AML-M0 47,XY,t(7;12)(q36,p13),+der(19) YAC 964c10 (12p13)
ETV6 exon
specific cosmids
PAC H_DJ1121A15 (7q36)
Cos 121b1 (7q36)
Cos 227e6 (7q36)
Cos 107a07 (7q36)
Cos 148a04 (7q36)
Cos 85c10 (7q36)
Cos 133f02 (7q36)
Three colour FISH
probe
pt 5 in [2]





pt 3 in [12]



Pt 2 in [10]
Confirmed previous findings

4 MDS 46,XX,der(7)t(7;12)(q22;p13)del(7)
(q22q36)
YAC 964c10 (12p13)
ETV6 exon
specific cosmids
Various 7q22 and
7q36 probes
Three colour FISH
probe
pt 1 in [2]


pt 1 in [12]

pt 1 in [10]
Confirmed previous findings

Tosi et al.Hematology and Leukemia  2015 3:4DOI : 10.7243/2052-434X-3-4