Figure 3 : Kaplan-Meier survival curves factored for high digitally-quantified MIB-1 (>93%) andfactored for high reported MIB-1 (>65%) - time in months

A digitally-quantified MIB-1 proliferation indices demonstrated significance with overall survival in the whole patient cohort (HR 1.6 (0.2 -10.6); p=0.05) when compared with B semi-quantified (SQ) values (HR 1.6 (0.2-10.6); p=0.6) ; C digitally-quantified MIB-1 proliferation indices demonstrated significance with progression free survival in the whole patient cohort (HR 2.8 (0.6-13.5); p=0.05) when compared with D semi-quantified values (HR 0.4 (0.2-1.2); p=0.1).