Abstract

Background: Kaposi sarcoma (KS) is a local aggressive angioproliferative tumor with various stages having different histopathological findings. Histopathological findings have a diagnostic value depending on at what stage, how often, and with what findings they are observed. The study aimed to determine the finding or a group of findings which is prominent in different stages of KS and which can effectively identify that stage.

Methods: KS cases diagnosed were retrospectively reviewed. The relationship between morphological parameters and disease stages was investigated. In comparative analysis, Chi Square test and multivariate regression analysis were used. Statistical significance level was accepted as p<0.05.

Results: When different stage groups and the frequency of parameters were compared, there was statistical significance; the multivariate regression analysis revealed that the presence of hemosiderin in the plaque stage was OR: 25.7 (p: 0.02; CI 95%: 1.6-398.2) times higher than that of patch stage, and the presence of mitosis in the nodule stage was OR: 3,7 (p: 0,002; CI 95%:3,8 - 489,7) higher than that of plaque stage. It was statistically significant.

Conclusion: The diagnosis of KS will be safer if evaluated with the most valid and best-defining histopathological findings of the related stage.

Keywords: Kaposi sarcoma, histopathology, stage, frequency