Table 3. The expression of asRNAs from IL-1b-inducible genes in rat hepatocytes.


Group ARE1 asRNA No. of genes Gene product2

1 (+) (+) 16 CCL2, CCL20, CD69, CXCL1, CX3CL1,
FAM89A, GPRK5, IL-23A, iNOS3, IkB-a,
NF-kB p65, NF-kB p50, phospholipid scramblase 1,
RUNX1, semaphorin 4A, STEAP 4
2 (+) (–) 5 Calcitonin-related polypeptide b,
carbonic anhydrase II, CCL7, IL-1b, SMPD3
3 (–) (+) 3 Lymphotoxin b, PSMB10, Toll-like receptor 2
4 (–) (–) 1 CDKN2B

    Total 25  

1. AU-rich element(s) (ARE) present (+) or absent (–) in the mRNA 3'UTR.

2. Genes that were significantly induced (i.e., at least a 2-fold increase in signals) in a microarray analysis are shown. Genes to which the NATRE technology was applied are underlined. CXCL1, chemokine C-X-C motif ligand 1; FAM89A, family with sequence similarity 89, member A; GPRK5, G protein-coupled receptor kinase 5; iNOS, inducible nitric oxide synthase; RUNX1, runt-related transcription factor 1; STEAP4, six-transmembrane epithelial antigen of prostate 4; SMPD3, neutral sphingomyelin phosphodiesterase 3; PSMB10, proteasome subunit, β type 10; CDKN2B, cyclin-dependent kinase inhibitor 2B.

3. Matsui et al. [7].

Nishizawa et al.  2012 1:10DOI : 10.7243/2050-0874-1-10