Figure 2 : Chronic social defeat activated the HPA axis and
induced depression-like behavior.

(A) The average plasma CORT levels after chronic social defeat were
significantly elevated in submissive mice compared to dominant mice
and controls. There was no ignificant difference in plasma CORT levels
between dominant and control mice. (n=8-10 mice per experimental
group). (B) The average total time spent immobile during the forced
swim test was increased in submissive mice compared to dominant
mice and controls. There was no significant difference in the total
time spent immobile in the forced swim test between dominant and
control mice. (n=7-10 mice per experimental group). *indicates
statistical significance of p<0.05 using a one-way ANOVA with
Tukey’s post hoc test.

Maguire et al.Hormonal Studies  2014 2:2DOI : 10.7243/2052-8000-2-2