Hormonal Studies

Hormonal Studies

ISSN 2052-8000

CIN85 defect in brain and neurobehavioral disorder: involvement in excess dopamine signaling

Noriaki Shimokawa*, Shinnosuke Masuda, Hiroko Masuda and Noriyuki Koibuchi

*Correspondence: Noriaki Shimokawa simokawa@med.gunma-u.ac.jp

Authors Affiliation:

Department of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.


The Cbl-interacting protein of 85 kDa (CIN85) belongs to a family of ubiquitously expressed adaptor/scaffold proteins. CIN85 interacts with endocytic proteins involved in various receptor signaling pathways. Despite extensive investigations of CIN85 in receptor trafficking, little is known about its functions in vivo. Mice deficient in brain-specific CIN85 expression show hyperactive phenotypes, which in many ways resemble the behavioural aberrations displayed in human beings affected by attention deficit/hyperactivity disorder (ADHD), a disorder strongly associated with abnormal dopamine signaling. ADHD is a neurobehavioural disorder characterized by either significant difficulties of inattention or hyperactivity and impulsiveness or a combination of the two. While genetic factors are strongly implicated in the etiology of ADHD, the genes responsible for ADHD are unknown. Here, we review the recent progress of CIN85 study and the possibility of ADHD onset owing to CIN85 defect in the brain.

Keywords: CIN85, dopamine signaling, CIN85 deficient mouse, attention deficit/hyperactivity disorder

ISSN 2052-8000
Volume 1
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