Figure 3 : Localization of DCLK1 positive cells along the intestinal crypt. DCLK1 positive cells co-express neuroendocrine markers and can be found either at the crypt base among the Paneth cells or above the crypt base in an area which includes the +4 compartment were quiescent stem cells are thought to reside. Crypt base DCLK1 positive cells are also positive for LGR5 while DCLK1 positive cells above the crypt base are LGR5 negative but may express other markers of quiescent stem cells such as SOX9 and BMI1. In the upper part of the crypt a mature neuroendocrine cell is depicted.