Author 
Year 
Age 
Sex 
Presenting symptom 
Synchronous or metachronous 
First sign of RCC? 
RCC 
Other simultaneous mets? 
Fine Needle aspiration 
Treatment 
Immunohistochemistry 
Patey et. al. 
1965 
63 
F 
Pulsatile mass x1 year 
Metachronous 
Y 
RCC dx years later 
Not discussed 
Not mentioned 
Radiotherapy and excision 
None mentioned 
Kucan et. al. 
1981 
55 
M 
Mass x34mo. on R. 
Synchronous 
Y 
RCC dx on subsequent work up 
Not discussed 
Not mentioned 
Superficial parotidectomy 
None mentioned 
Sist et. al. 
1982 
62 
M 
Mass x2 years on L. 
Synchronous 
Y 
R. RCC dx in subsequent work up 
Not discussed 
Not mentioned 
Deep parotidectomy w/ preservation of the facial nerve 
None mentioned 
Percival et. al. 
1982 
71 
F 
Mass x 3 years on R. 
Synchronous 
Y 
L. RCC dx one year later 
Liver, lung 
Not mentioned 
Surgical excision 
None mentioned 
Smits et. al. 
1984 
60 
F 
Painful mass on R. 
Metachronous 
N 
R. nephrectomy for RCC 8.5 years earlier 
Submandibular gland 
Not mentioned 
Excision of mass 
None mentioned 
Hessan et. al. 
1986 
52 
M 
Mass x2mo. on L. 
Synchronous 
Y 
L. RCC dx in subsequent work up 
None at time of parotid presentation, later lungs, ribs, lumbar spine, and brain mets. 
Not mentioned 
Superficial parotidectomy 
None mentioned 
Harrison et. al. 
1987 
64 
F 
Mass x2mo.on R., R. superficial parotidectomy 4 years prior for "clear cell tumor" 
Metachronous 
N 
Nephrectomy for RCC 10 years prior 
None 
Not mentioned 
Excision of lesions 
None mentioned 
Owens et. al. 
1989 
55 
M 
Mass x3mo. on R. 
Synchronous 
Y 
L. RCC dx in subsequent work up 
Chest, brain, bone 
Not mentioned 
Superficial parotidectomy w/ partial excision of masseter 
None mentioned 


75 
F 
Pulsatile mass x10 weeks on L. 
Metachronous 
N 
R. nephrectomy for RCC 7 years prior 
None at time of parotid presentation, later recurrent renal disease. 
Not mentioned 
Total parotidectomy w/ preservation of the facial nerve 
None mentioned 
Melnick et. al. 
1989 
72 
M 
Mass x2.5 years on L. 
Synchronous 
Y 
R. RCC dx in subsequent work up 
Liver, lungs, mediastinum, adrenal 
FNA nondiagnostic 
Palliative radiotherapy 
Positive for vimentin and keratin. Negative for CEA. 
Gunbay et. al. 
1989 
60 
M 
Painful mass on L. and numbness of L. commisure of lip x1mo. 
Metachronous 
N 
L. nephrectomy for RCC 2 years prior 
Not discussed 
Not mentioned 
Total parotidectomy of mass extending into pterygomaxillary fossa w/ erosion of condylar process of the mandible and the TMJ 
None mentioned 
Coppa et. al. 
1990 
42 
M 
Mass on L. x3 years, pulsatile x1 year, tinnitus x1 mo. 
Synchronous 
Y 
R. RCC dx in subsequent work up 
Perirenal lymph nodes 
Not mentioned 
Superficial parotidectomy w/facial nerve preservation 
None mentioned 


55 
M 
Painful mass x6 weeks on R., bruit 
Metachronous 
N 
L. nephrectomy for RCC 7 years prior 
Lungs, axillary lymph nodes 
Not mentioned 
R. external carotid ligation and multiple partial parotid resections for recurrent bleeding. 
None mentioned 
Pisani et. al. 
1990 
59 
M 
Mass x2mo. on L. 
Synchronous 
Y 
L. RCC dx in subsequent work up 
Cerebellar, vertebral 
Not mentioned 
Superficial parotidectomy w/ preservation of the facial nerve followed by subsequent hemorrhage and several excisions for recurrent disease 
None mentioned 
Sarangi et. al. 
1991 
71 
M 
Mass in L. parotid x3mo at presentation, R. parotid mass presented 4 mo. later. 
Synchronous 
Y 
R. RCC dx in subsequent work up 
None at time of parotid presentations, later mets to distal radius. 
Not mentioned 
L. superficial parotidectomy followed by R. superficial parotidectomy. 
None mentioned 
Ravi et. al. 
1992 
55 
F 
Bilateral masses x3mo. 
Metachronous 
N 
R. nephrectomy for RCC 7 years prior 
Not discussed 
Not mentioned 
Superficial parotidectomies w/ preservation of the facial nerves on two separate occasions 
None mentioned 
Borghi et. al. 
1995 
63 
M 
Mass x1 year on R. 
Synchronous 
Y 
L. RCC dx in subsequent work up 
Liver, pancreas 
FNA nondiagnostic 
Partial parotidectomy 
Positive for vimentin, CAM5.2, AE1. Negative for S100, CEA. 
Sykes et. al. 
1995 
59 
M 
Mass x3 weeks on L. 
Synchronous 
Y 
L. RCC dx in subsequent work up 
Perirenal lymph nodes 
FNA nondiagnostic 
Superficial parotidectomy w/ preservation of the facial nerve 
None mentioned 
Gangopadhyay et. al. 
1998 
48 
M 
Mass x3mo. on L. 
Synchronous 
Y 
L. RCC dx in subsequent work up 
R. adrenal 
FNA nondiagnostic 
Superficial parotidectomy 
None mentioned 
Vara et. al. 
1998 
50 
M 
Painful mass x2mo. on L. 
Metachronous 
N 
R. nephrectomy 5 years prior 
Not discussed 
Not mentioned 
Total parotidectomy w/ preservation of facial nerve, locally recurrent in 7mo., repeat excision w/radiotherapy 
None mentioned 
Adil et. al. 
1999 
52 
M 
Mass on R. 
Synchronous 
N 
L. nephrectomy for RCC 5 mo. prior 
Postauricular lymph nodes at time of parotid presentation, later paraaortic, inguinal, and cervical lymph nodes. 
Not mentioned 
Mass excision, neck dissection 
None mentioned 
Kundu et. al. 
2001 
61 
M 
R. facial weakness and postauricular pain, R. mass on physical exam. 
Synchronous 
Y 
L. RCC dx in subsequent work up 
R. adrenal, bone, skin, pulmonary, cerebral 
FNA nondiagnostic 
Radiotherapy, pain relief, hospice 
None mentioned 
Park et. al. 
2002 
83 
F 
Mass x2mo. on L. 
Metachronous 
N 
L. nephrectomy for RCC 10 years prior 
None 
FNA diagnostic 
Superficial parotidectomy with preservation of the facial nerve 
Positive for vimentin and keratin. Negative for CEA. 
Seijas et. al. 
2005 
67 
M 
Mass x4mo. on L. 
Synchronous 
Y 
R. RCC dx in subsequent work up 
L. adrenal at time of parotid presentation, later lungs, R. adrenal, retroparitoneal lymph nodes 
FNA nondiagnostic 
Superficial parotidectomy with preservation of the facial nerve 
Positive for CAM5.2, AE3, vimentin. Negative for S100, CK7, CK20, EMA. 
Mrena et. al. 
2008 
58 
F 
Tender mass on R. 
Synchronous 
Y 
R. RCC dx in subsequent work up 
None at time of presentation, R. shoulder mets later identified. 
FNA nondiagnostic 
Superficial parotidectomy 
Positive for CD10, PNRA, vimentin. Partially positive for pancytokeratin (AE1/AE3). Negative for calponin, S100, and cytokeratin7. 


76 
F 
R. mass on physical exam 
Metachronous 
N 
L. nephrectomy for RCC 9 years prior 
Contralateral kidney, lung, bone 
FNA nondiagnostic 
Not described 
Positive for CD10, PNRA, vimentin. Negative for cytokeratin7. 


62 
M 
L. mass for a few years 
Metachronous 
N 
R. nephrectomy for RCC 5 years prior 
None 
FNA nondiagnostic 
Superficial parotidectomy and selective neck dissection (IIIII) 
Positive for CD10, vimentin, CAM5.2. Partially positive for CK8 and CK18. Negative for cytokeratin7. 
Spreafico et. al. 
2008 
67 
M 
R.mass on physical exam 
Metachronous 
N 
R. nephrectomy for RCC 18 mo. prior 
Ipsilateral cervical lymph nodes 
FNA diagnostic 
Total parotidectomy and selective neck dissection (IV) w/removal of large portion of masseter and inferior facial nerve 
None mentioned 
Wayne et. al. 
2010 
61 
F 
L. mass on physical exam 
Metachronous 
Y 
No primary 
Pancreas, skin 
Not mentioned 
Superficial parotidectomy 
Positive for PNRA, vimentin, CD10. 
Deeb et. al. 
2010 
82 
M 
R. mass x1.5 years, pain 
Metachronous 
N 
Partial nephrectomy for RCC 19 years prior, completion nephrectomy 4 years prior 
Not discussed 
FNA nondiagnostic 
Total parotidectomy 
None mentioned 
Table 1. Summary of all complete case presentations of RCC metastatic to the parotid gland dating from 1965 to present.
R.: right, L.: left, RCC: renal cell carcinoma, mets: metastasis