Author

Year

Age

Sex

Presenting

symptom

Synchronous or metachronous

First sign of RCC?

RCC

Other simultaneous mets?

Fine

Needle

aspiration

Treatment

Immunohistochemistry

Patey et. al.

1965

63

F

Pulsatile mass x1 year

Metachronous

Y

RCC dx years later

Not discussed

Not mentioned

Radiotherapy and excision

None mentioned

Kucan et. al.

1981

55

M

Mass x3-4mo. on R.

Synchronous

Y

RCC dx on subsequent work up

Not discussed

Not mentioned

Superficial parotidectomy

None mentioned

Sist et. al.

1982

62

M

Mass x2 years on L.

Synchronous

Y

R. RCC dx in subsequent work up

Not discussed

Not mentioned

Deep parotidectomy w/ preservation of the facial nerve

None mentioned

Percival et. al.

1982

71

F

Mass x 3 years on R.

Synchronous

Y

L. RCC dx one year later

Liver, lung

Not mentioned

Surgical excision

None mentioned

Smits et. al.

1984

60

F

Painful mass on R.

Metachronous

N

R. nephrectomy for RCC 8.5 years earlier

Submandibular gland

Not mentioned

Excision of mass

None mentioned

Hessan et. al.

1986

52

M

Mass x2mo. on L.

Synchronous

Y

L. RCC dx in subsequent work up

None at time of parotid presentation, later lungs, ribs, lumbar spine, and brain mets.

Not mentioned

Superficial parotidectomy

None mentioned

Harrison et. al.

1987

64

F

Mass x2mo.on R., R. superficial parotidectomy 4 years prior for "clear cell tumor"

Metachronous

N

Nephrectomy for RCC 10 years prior

None

Not mentioned

Excision of lesions

None mentioned

Owens et. al.

1989

55

M

Mass x3mo. on R.

Synchronous

Y

L. RCC dx in subsequent work up

Chest, brain, bone

Not mentioned

Superficial parotidectomy w/ partial excision of masseter

None mentioned

 

 

75

F

Pulsatile mass x10 weeks on L.

Metachronous

N

R. nephrectomy for RCC 7 years prior

None at time of parotid presentation, later recurrent renal disease.

Not mentioned

Total parotidectomy w/ preservation of the facial nerve

None mentioned

Melnick et. al.

1989

72

M

Mass x2.5 years on L.

Synchronous

Y

R. RCC dx in subsequent work up

Liver, lungs, mediastinum, adrenal

FNA non-diagnostic

Palliative radiotherapy

Positive for vimentin and keratin.  Negative for CEA.

Gunbay et. al.

1989

60

M

Painful mass on L. and numbness of L. commisure of lip x1mo.

Metachronous

N

L. nephrectomy for RCC 2 years prior

Not discussed

Not mentioned

Total parotidectomy of mass extending into pterygomaxillary fossa w/ erosion of condylar process of the mandible and the TMJ

None mentioned

Coppa et. al.

1990

42

M

Mass on L. x3 years, pulsatile x1 year, tinnitus x1 mo.

Synchronous

Y

R. RCC dx in subsequent work up

Perirenal lymph nodes

Not mentioned

Superficial parotidectomy w/facial nerve preservation

None mentioned

 

 

55

M

Painful mass x6 weeks on R., bruit

Metachronous

N

L. nephrectomy for RCC 7 years prior

Lungs, axillary lymph nodes

Not mentioned

R. external carotid ligation and multiple partial parotid resections for recurrent bleeding.

None mentioned

Pisani et. al.

1990

59

M

Mass x2mo. on L.

Synchronous

Y

L. RCC dx in subsequent work up

Cerebellar, vertebral

Not mentioned

Superficial parotidectomy w/ preservation of the facial nerve followed by subsequent hemorrhage and several excisions for recurrent disease

None mentioned

Sarangi et. al.

1991

71

M

Mass in L. parotid x3mo at presentation, R. parotid mass presented 4 mo. later.

Synchronous

Y

R. RCC dx in subsequent work up

None at time of parotid presentations, later mets to distal radius.

Not mentioned

L. superficial parotidectomy followed by R. superficial parotidectomy.

None mentioned

Ravi et. al.

1992

55

F

Bilateral masses x3mo.

Metachronous

N

R. nephrectomy for RCC 7 years prior

Not discussed

Not mentioned

Superficial parotidectomies w/ preservation of the facial nerves on two separate occasions

None mentioned

Borghi et. al.

1995

63

M

Mass x1 year on R.

Synchronous

Y

L. RCC dx in subsequent work up

Liver, pancreas

FNA non-diagnostic

Partial parotidectomy

Positive for vimentin, CAM5.2, AE1.  Negative for S-100, CEA.

Sykes et. al.

1995

59

M

Mass x3 weeks on L.

Synchronous

Y

L. RCC dx in subsequent work up

Perirenal lymph nodes

FNA non-diagnostic

Superficial parotidectomy w/ preservation of the facial nerve

None mentioned

Gangopadhyay et. al.

1998

48

M

Mass x3mo. on L.

Synchronous

Y

L. RCC dx in subsequent work up

R. adrenal

FNA non-diagnostic

Superficial parotidectomy

None mentioned

Vara et. al.

1998

50

M

Painful mass x2mo. on L.

Metachronous

N

R. nephrectomy 5 years prior

Not discussed

Not mentioned

Total parotidectomy w/ preservation of facial nerve, locally recurrent in 7mo., repeat excision w/radiotherapy

None mentioned

Adil et. al.

1999

52

M

Mass on R.

Synchronous

N

L. nephrectomy for RCC 5 mo. prior

Post-auricular lymph nodes at time of parotid presentation, later para-aortic, inguinal, and cervical lymph nodes.

Not mentioned

Mass excision, neck dissection

None mentioned

Kundu et. al.

2001

61

M

R. facial weakness and post-auricular pain, R. mass on physical exam.

Synchronous

Y

L. RCC dx in subsequent work up

R. adrenal, bone, skin, pulmonary, cerebral

FNA non-diagnostic

Radiotherapy, pain relief, hospice

None mentioned

Park et. al.

2002

83

F

Mass x2mo. on L.

Metachronous

N

L. nephrectomy for RCC 10 years prior

None

FNA diagnostic

Superficial parotidectomy with preservation of the facial nerve

Positive for vimentin and keratin. Negative for CEA.

Seijas et. al.

2005

67

M

Mass x4mo. on L.

Synchronous

Y

R. RCC dx in subsequent work up

L. adrenal at time of parotid presentation, later lungs, R. adrenal, retroparitoneal lymph nodes

FNA non-diagnostic

Superficial parotidectomy with preservation of the facial nerve

Positive for CAM5.2, AE3, vimentin.  Negative for S-100, CK7, CK20, EMA.

Mrena et. al.

2008

58

F

Tender mass on R.

Synchronous

Y

R. RCC dx in subsequent work up

None at time of presentation, R. shoulder mets later identified.

FNA non-diagnostic

Superficial parotidectomy

Positive for CD10, PNRA, vimentin. Partially positive for pancytokeratin (AE1/AE3). Negative for calponin, S-100, and cytokeratin-7.

 

 

76

F

R. mass on physical exam

Metachronous

N

L. nephrectomy for RCC 9 years prior

Contralateral kidney, lung, bone

FNA non-diagnostic

Not described

Positive for CD10, PNRA, vimentin. Negative for cytokeratin-7.

 

 

62

M

L. mass for a few years

Metachronous

N

R. nephrectomy for RCC 5 years prior

None

FNA non-diagnostic

Superficial parotidectomy and selective neck dissection (II-III)

Positive for CD10, vimentin, CAM5.2. Partially positive for CK-8 and CK-18.  Negative for cytokeratin-7.

Spreafico et. al.

2008

67

M

R.mass on physical exam

Metachronous

N

R. nephrectomy for RCC 18 mo. prior

Ipsilateral cervical lymph nodes

FNA diagnostic

Total parotidectomy and selective neck dissection (I-V) w/removal of large portion of masseter and inferior facial nerve

None mentioned

Wayne et. al.

2010

61

F

L. mass on physical exam

Metachronous

Y

No primary

Pancreas, skin

Not mentioned

Superficial parotidectomy

Positive for PNRA, vimentin, CD10.

Deeb et. al.

2010

82

M

R. mass x1.5 years, pain

Metachronous

N

Partial nephrectomy for RCC 19 years prior, completion nephrectomy 4 years prior

Not discussed

FNA non-diagnostic

Total parotidectomy

None mentioned

Table 1. Summary of all complete case presentations of RCC metastatic to the parotid gland dating from 1965 to present. 

R.: right, L.: left, RCC: renal cell carcinoma, mets: metastasis

 

Wein et al.Journal of Cancer Therapeutics and Research  2012 1:15DOI : 10.7243/2049-7962-1-15